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Therefore, antihistamines do not stop the allergic reaction but protect tissues from some of its effects.

Antihistamines frequently cause mouth dryness and sleepiness.

Histamine is released as a reaction to foreign substances (allergens), and starts a chain reaction that leads to the release of other chemicals that add to the allergic response. There are two different types of antihistamine; sedating antihistamines, which can enter the brain and cause drowsiness and non-sedating antihistamines which do not.

So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.

Cohen, MD, an allergist in Milwaukee who serves as spokesman for the American Academy of Allergy, Asthma and Immunology.

That study was sponsored by the company that manufactures Allegra.

Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.

"We're not saying that there's not a difference," says lead researcher Bruce G.

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