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Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients.However, some patients may require treatment despite the presence of the syndrome.(For further information about the description of tardive dyskinesia and its clinical detection, please refer to "Information for Patients" in the PRECAUTIONS section, and to the ADVERSE REACTIONS section.) A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs, including thiothixene.There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn.

However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses.The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.Given these considerations, antipsychotics should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia.If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered.The patient should be carefully monitored, since recurrences of NMS have been reported.

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