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There are several co-factors required to make the most commonly used serotonin supplements do their job.

Conversely, there are times when these supplements can react adversely with medications or other serotonin supplements, and you need to know about those, too.

There are many kinds of nutritional supplements that increase serotonin levels — amino acids, vitamins, minerals, herbs, and more.But SSRIs can have serious side effects and don’t work for everyone, possibly up to 40 percent of those who try them (1).Some research shows they work no better than a placebo (2).It’s believed that low serotonin is the underlying cause of depression.Selective serotonin reuptake inhibitors (SSRIs) such as Paxil, Prozac, Zoloft, Celexa, and Lexapro are used by millions to relieve symptoms of depression by increasing brain levels of serotonin.

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